January 18, 2018 at 4:42 am #894
I was already planning on getting Nootropics, and then having them tradeable for Temple Coins, and this is basically in the same strain of products; but I decided I am going to start getting Generic Powder forms of over the Counter Medicines in Bulk in Foreign Countries, then having them packaged somewhere and then sell them in the United States over the Counter as our own brand.
And our Brand is going to be different, for example, the first thing I want to offer is Clemastine
For some reason it is fairly expensive over the Counter, but is meant to do nothing more than Benadryll really. But what we will sell it for it 2 fold. As an Anti-Histamine, like Benadryll, but we will also let people know that it causes Remyelination, which forms Oligodendrocytes.
Oligodendrocytes (from Greek, meaning cells with a few branches), or oligodendroglia, are a type of neuroglia discovered by Pío del Río Hortega. Their main functions are to provide support and insulation to axons in the central nervous system of some vertebrates, equivalent to the function performed by Schwann cells in the peripheral nervous system. Oligodendrocytes do this by creating the myelin sheath, which is 80% lipid and 20% protein. A single oligodendrocyte can extend its processes to 50 axons, wrapping approximately 1 μm of myelin sheath around each axon; Schwann cells, on the other hand, can wrap around only one axon. Each oligodendrocyte forms one segment of myelin for several adjacent axons.
Here is the World Anti-Doping List, which only applies to Professional Athletes
Better Understanding Nootropics
There is a class of Chemicals known as Nootropics, or Smart Drugs; They are prescribed in many other Countries, but in the US they are just “Not FDA Approved”. It is hard to figure out what is what, so I am going to explain them in a way that makes it all a lot more simple. Everyone knows what Tryptophan is, Tryptophan is in Turkey, but not in high enough amounts to make you tired. You can get Tryptophan Powder, and you could even buy it by the Barrel on Alibaba, and it is a sleep aid better than Melatonin. Melatonin is another example of a Nootropic, but it has basically defined the laws for FDA non-approved remedies, and has not really been considered a Nootropic. But Melatonin is a sleep Regulator, Tryptophan is a sleep Aid.
Tryptophan is related to Tryptamine, with is in DMT, which many people have probably heard of. And Melatonin is related to Serotonin. Another example of something closely related to Serotonin is 5-HTP, which is 5-Hydroxytryptophan. Then there are Cholergenics. People have probably heard that Nicotine can induce Dreams, and that if you wear a Nicotine patch and aren’t a smoker, it can cause Dreams. Nicotine is Cholerginic. Choline is in Milk, it is in Eggs, it is in a lot of different things, and you can buy pure Choline Powder. But you can also get Alpha-GPC, because Choline mostly is destroyed by your Stomache acids, so Alpha-GPC is more bio-Available. Then, once you have Choline in your system, what it does is create Acetylcholine, which Regulates Thoughts and Dreams. So once you have the Choline, you can activate it. You can do that with Piracetam, or Phenylpiracitam, which cause your brain to use it’s Acetylcholine. You can also get Galantamine, which is an Acetylcholine Esterase Inhibitor. The way this works is similar to an SSRI, but for a completely different part of the brain. Acetylcholine Regulates Thought and Dreams. Acetylcholine Esterase is an Ezyme that breaks down any “extra” Acetylcholine your brain makes. And Acetylcholine Esterase Inhibitor, inhibits the action of the Acetylcholine Esterase, so that all Acetylcholine created is used and none is wasted.
Then there are things like Octopamine, which is in Bitter Orange Peel. It is similar to Caffeine, but is related to Adrenaline, so it is more natural. And there are other similar Nootropics. As well as things like GABA, which can help you relax or sleep. Then there is Modafinil which is a Prodrug of Provigil, and breaks down in the stomache to do the exact same thing. So when getting a Nootropic, you just have to figure out how it relates to Human Biochemistry, and maybe figure out what the plant equivalent is.
January 18, 2018 at 4:51 am #896
- This topic was modified 3 months ago by shaivi5_wp.
Analogues of Schedule III, IV or V substances are not regulated. So things like Alprazolam (Xanax) Analogues, Marinol Analogues, Ketamine Analogues, Testosterone Analogues, are all unregulated. Only Analogues of Schedule I and II Substances are regulated.January 18, 2018 at 5:19 am #897
CYP450 ENZYME OTC DRUGS
Here is how it works
CYP Enzymes (Drug Metabolism, etc)
Induction and Inhibition (Anti-Oxidants, etc)
Graviola- 5-HT1a Agonist
Black Cohosh- 5-HT1A, 5-HT1D & 5-HT7 Binding
C. Foetida L.- 5-HT1A Agonist
Yokukansan- 5-HT1A Agonist
DMT hits all of these, and can be found in tons of plants.
Black Cohosh- 5-HT1D
maybe Rhodiola rosea, Albizia lebbeck & Albizia julibrissin.
5-HT1 Receptor Agonists:
Turmeric, Ginger, Ginko Bilboa, Lemon Essential Oil, Rauwolfia, Valerian, Yohimbe
Elmicin & Myristicin (in Nutmeg)- 5-HT2A Agonist
Estragole (in Sweet Basil)- 5-HT2A Agonist
Safrole (in Sassafras)- 5-HT2A Agonist
Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver’s Glutithione) Taken 1 Hour before Allybenzene,
Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor
German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)
GoldenSseal & Echinacea purpurea very effectively do the same thing.
Black seed oil, 50% EGCG, Valerian root oil, Pomegranate, Vitamin B9, 40% Ellagic extract, Rooibos 20% Gallic acid extract, Rutin, B3 & Kudzu
Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,
since Cinnamon is a Phenylpropanoid, and Phenylpropanoids are made from Phenelalamine, and people who took Phenelalamine claim to get better results. I decided to post a list of Phenylpropanoids also.
Caffeyl Alcohol, Cinnamaldehyde, Cinnamyl alcohol, alpha-Cyno-4-hydroxycinnamic acid, Ethyl Cinnamate, Lignin, 2,4-Methlenedioxypropiophenone, Neoflavonoids, Nordihydroguaiaretic acid, Phenylpropanoic acid, Phloretic acid, Rhododendrin & Suberin.
Star Anise Extract or B9 for CYP2C9 Induction
NMDA Receptor Plants:
Most important things:
Alcohol Dehydrogenase Induction
Aldehyde Dehydrogenase Inhibition
Piperidine and or Dimethylamine Supplementation
Methyl from foods
Exercise or compounds that produce effects like exercise
Less important, but still factors:
SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine)
Hungarian Parsley Seed is a better source of Myristicin than Nutmeg. The effects of it when activated properly are said to be like Mescaline and MDMA together. The P450 Enzymes CYP1A2 & CYP3A4 are what break this down and need to be inhibited. CYP2D6 could also play a big role.
Elmicin is something you either need Chromotography type knowledge to get, or you have to buy it in small quantities. When activated properly it is like Mescaline, when activated wrong it is like Melatonin (sleepy). CYP1A1, CYP1B1, CYP1A2, CYP2A6, CYP2C9, CYP2A6, CYP2C9 & CYP2E1 are what are needed to be inhibited to activate this. CYP2D6 could also play an important role.
Safrole is like MDMA when activated properly and like Melatonin when not. CYP2A6, CYP2C9, and CYP2E1 are most important for this. CYP2D6 could also be important.
Methyl Chavicol when activated properly is like a light speedy LSD, when activated wrong it is said to be almost like Marijuana. CYP1A2 and CYP2A6 inhibit it, and CYP2D6 could also be important.
If the CYP2D6 Enzyme is inhibited with all the others, these are possibly visually hallucinogenic Oilahuascas. And the Methyl Chavicol doesn’t build a tolerance (the others do) it actually gets stronger for you every time you use it, or you can use less.
Several allylbenzenes have been proven to form up to 3 alkaloid metabolites after ingestion by several animals. They do not form amphetamines in vivo as has been speculated in the past. The alkaloids detected in animal urine are tertiary aminopropiophenones of 3 possible subtypes: dimethylamines, piperidines, and pyrrolidines.
The allylbenzene elemicin has been proven to form all 3 different alkaloid metabolites after ingestion in animals by analyzing urine using gas-liquid chromatography and chemical ionization mass spectrometry.
Safrole is also proven to form all three alkaloid metabolites after ingestion.
Myristicin appears to only form piperidines and pyrrolidines. Dimethylamines of myristicin have not been detected.
Allylbenzene, from which all allylbenzenes are derived, forms piperidine and dimethylamine alkaloids.
Propenylbenzene and its derivatives (asarone, anethole, etc.) do not form alkaloid metabolites.
1. Handbook of phytochemical constituents of GRAS herbs and other economic plants
Duke, James A. 1992. Boca Raton, FL. CRC Press (Dr. Duke’s Phytochemical and Ethnobotanical Databases Online)
2. Unpublished scientific research performed by members of herbs.maxforum.org.
3. Content of Potentially Anticarcinogenic Flavonoids of Tea Infusions,
Wines, and Fruit Juices Michael G. L. Hertog, Peter C. H. Hollman, and Betty van de Putte. 1993. DOI: 10.1021/jf00032a015
4. Safety evaluation of certain food additives; Prepared by the Sixty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA); World Health Organization, Geneva, 2009; ISBN: 978-92-4-166060-0
IARC MONOGRAPHS – 101 Download Attached PDF Document
6. Douglas W. Bristol, Ph.D., Study Scientist
NTP Technical Report on the 3-Month Toxicity Studies of Estragole; National Toxicology Program, Toxicity Report Series, Number 82; NIH Publication No. 11-5966; National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services Download Attached PDF Document
7. Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling.
Punt A, Jeurissen SM, Boersma MG, Delatour T, Scholz G, Schilter B, van Bladeren PJ, Rietjens IM. PubMed: 19920071
8. Glucuronidation of 1′-hydroxyestragole (1′-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9.
Iyer LV, Ho MN, Shinn WM, Bradford WW, Tanga MJ, Nath SS, Green CE. PubMed: 12657745
9. Immunochemical identification of hepatic protein adducts derived from estragole.
Wakazono H, Gardner I, Eliasson E, Coughtrie MW, Kenna JG, Caldwell J. PubMed: 9705747
10. Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation.
Sakano K, Inagaki Y, Oikawa S, Hiraku Y, Kawanishi S. PubMed PMID: 15576237
11. Yun CH, Lee HS, Lee HY, Yim SK, Kim KH, Kim E, Yea SS, Guengerich FP
Department of Genetic Engineering, Pai-Chai University, 439-6 Doma-dong, Seo-ku, Taejon 302-735, South Korea. Toxicology Letters [2003, 137(3):143-150]; Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin; DOI: 10.1016/S0378-4274(02)00397-1 PubMed PMID 12523956
12. Amunom I, Dieter LJ, Tamasi V, Cai J, Conklin DJ, Srivastava S, Martin MV, Guengerich FP, Prough RA.
Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes; Department of Biochemistry and Molecular Biology, The University of Louisville School of Medicine , Louisville, KY 40292, USA; Chem Res Toxicol. 2011 Aug 15;24(8):1223-30. doi:
10.1021/tx200080b. Epub 2011 Jul 29; PubMed PMID: 21766881January 18, 2018 at 5:27 am #900January 18, 2018 at 2:44 pm #903
This information can be used for bodybuilding, and has been, but should also be used in long term Wound Treatment.
A lot of people know what Creatine is, but it is thought of as a bodybuilding supplement, you won’t hear your Doctor suggest taking Creatine for anything because your Doctor probably thinks of it as a bodybuilding supplement. Creatine is a very normal part of everyday body health, for example, when they test steak to see what quality the steak is, the higher the Creatine levels, the better the steak.
This paper shows that Creatine helps protect from Spinal Cord Injury
This paper shows that Creatine can help after Spinal Cord Injury
There are other Molecules similar to Amino Acids that are suggested by Doctors, such as Arganine, but Creatine should be used along side Arganine for the best results. Another Amino Acid that could be used is Citrulline. All of these are closely related and play a role in Muscle Health.
Then there is something that is not even close to anything being done by Doctors. S4 is a Selective Androgen Receptor Modulator, and would have various functions in Hospitals if used. S4 could be used to reduce atrophy, and for example, someone in a full body cast would be able to leave the Hospital with the same Muscle Mass as they came in with, people learning to walk again could rebuild leg Muscles faster and long term Wound Treatment could be a faster, easier process.
This paper explains the function of S4
This paper explains how S4 could be used for Spinal Injuries