January 18, 2018 at 7:20 am #902
You do not age because of time, but because of a process called Senescence, which the process of Cell Deterioration as your cells split over and over and over and over. Not everyone who is 20 years old has the same Biological Senescence rate. For example, a 60 year old could theoretically have the same Senescence rate as a 20 year old. The reason Senescence happens is because as your Cells split your DNA also splits. So every time a new Cell is made, your DNA is ripped apart. In order to not lose any of itself in this process, your DNA has what are called Telomeres. Telomeres exist at the ends of your DNA so that when your DNA splits you lose some of the Telomere instead of some of the DNA, but as your Cells split over and over and over, the Telomeres become shorter and shorter, causing Senescence. There are a few Animals that do not go through Senescence, and these Animals are known as Biologically Immortal. Examples are Lobsters, Jellyfish, Hydra & some Bacteria and Yeast, all of which can very easily live over 100-200 years in the wild and in some cases much longer. The Turritopsis Nutricula Jellyfish is considered to be truly Immortal.
Research into Life Extension and Immortality is closely linked to Cancer Research, in fact most Scientific Research in general right now is focused on DNA. But Life Extension and Cancer Research are almost one in the same in that Genomic Cancer Research has a lot to do with the fact that Tumors/Cancer are Immortal.
Papers about Telomeres in Cancer and Aging
These Papers are about Telomeres in Cancer
This Research Paper shows how DMSO (a common Solvent) can be used to Inhibit Telomerase. Telomerase is an enzyme that adds Nucleotides to Telomeres, effectively extending them. So Inhibiting Telomerase effectively limits the lifespan of Cancer cells.
These Papers explain Telomerase in Aging
hTERT is one of the most important Targets in this Research. This Paper explains how using hTERT, Human Cells can be Immortalized
These Papers explain the role of hTERT in Telomerase function and Cancer
This paper explains the roles of hTR and hTRT in Telomerase function and Cell Immortality
This paper explains a Molecule called Cycloastragenol, which has been shown to activate Telomrase
This Paper shows how Cycloastragenol can supress Lung Damage
These Papers explain Telemorization, which has been shown to create Immortal Cells
Antisense means, having a sequence of nucleotides complementary to (and hence capable of binding to) a coding sequence, which may be either that of the strand of a DNA double helix that undergoes transcription, or that of a messenger RNA molecule. Something that can do this is called an Antisense Agent. Examples are 2-MOE and 2-5A, here is a book about Antisense Drug Technology
Here are some Papers that explain Antisense in Cancer Treatment
Another important factor in all of this is a new field of Research known as Epigenetics. Epigenetics shows that your DNA can actually change based on different factors, and these changes in DNA over the course of your life can actually be passed down.
Here are some Papers that give an Overview of Epigenetics
And most Medical Research is focused on DNA at the moment, DNA has taken the place of Brain Study. Psychology was propelled forward by Cocaine, then LSD; and now DNA has taken its place.